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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Anesthesiology. 2015 Jun;122(6):1401–1413. doi: 10.1097/ALN.0000000000000619

Figure 4.

Figure 4

Adenosine monophosphate-activated protein kinase α (AMPKα) genetic knockdown through intrathecal small interfering RNA (siRNA) induced thermal hyperalgesia in naïve rats. (A) Bar graphs show the mean (± SEM) of the thermal withdrawal latency at baseline and after two days of intrathecal treatment (After treatment) in rats treated with AMPKα siRNA, Scrambled siRNA, or the iFect Vehicle. Data obtained from individual animals are shown in scatter plots. (B) Bar graphs show the mean (± SEM) relative density of AMPKα to β-Actin in the spinal dorsal horn of rats treated with AMPKα siRNA, Scrambled siRNA, or the iFect Vehicle. Data obtained from individual animals are shown in the scatter plots. Samples of each molecule protein expression in each group are shown. * p < 0.05, ** p < 0.01, and *** p < 0.001.