Table 4.
Germline mutation prevalences among pancreatic cancer probands with any biological family history of breast cancer, ovarian cancer, or melanoma. Results shown for probands who were tested for all four genes (total n=716).
| Gene | Deleterious Mutations n (%) | Variants of Uncertain Significance n (%) | ||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Probands with family history of pancreatic cancer AND family history of: | ||||||||
| Breast (n=264) | Ovarian (n=77) | Melanoma (n=77) | Any* (n=323) | Breast (n=264) | Ovarian (n=77) | Melanoma (n=77) | Any* (n=323) | |
|
|
|
|
||||||
| BRCA1 | 5 (1.9) | 4 (5.2) | 0 (0.0) | 5 (1.6) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| BRCA2 | 11 (4.2) | 4 (5.2) | 2 (2.6) | 14 (4.3) | 2 (0.8) | 0 (0.0) | 1 (1.3) | 2 (0.6) |
| PALB2 | 2 (0.8) | 0 (0.0) | 0 (0.0) | 2 (0.6) | 4 (1.5) | 3 (3.9) | 2 (2.6) | 7 (2.2) |
| CDKN2A | 3 (1.1) | 0 (0.0) | 6 (7.8) | 7 (2.2) | 6 (2.3) | 2 (2.6) | 5 (6.5) | 8 (2.5) |
| Total | 21 (8.0) | 8 (10.4) | 8 (10.4) | 28 (8.7) | 12 (4.5) | 5 (6.5) | 8 (10.4) | 17 (5.3) |
*
Any = Breast cancer, ovarian cancer, or melanoma