Figure 2.

Relative mRNA levels for MDR1 in MCF-7/ADR human multidrug-resistant breast cancer cells. MCF-7/ADR Cells transfected with different formulations and incubated for 24 or 48 hr. MDR1 mRNA downregulation efficiency was calculated by comparing the MDR1 mRNA expression value in each transfected group to the untreated group. The MDR1 mRNA expression value was normalized to β-actin. Data are means±SEM. (n=3; *P<0.05, *** P<0.001)

NLP: Nanolipoparticle; OFA: Oligofectamine; siC: Control siRNA; siM: MDR1 siRNA