Figure 4.

Enhancement of chemosensitivity to doxorubicin. Cytotoxicity of doxorubicin in MCF-7/ADR cells was assessed by MTT. Untransfected cells (control), cells transfected with liposomes containing MDR1 siRNA 100 nM (NLP siM, OFA siM) or cells transfected with empty NLP (NLP) or NLP containing control siRNA 100 nM (NLP siC) (as negative controls). After 48 hr, cells were incubated with 10 µM doxorubicin for 48 hr. Relative cell viability compared with control group has been reported. Data are means±SEM (n=3; ** P<0.01, *** P<0.001).

NLP: Nanolipoparticle; OFA: Oligofectamine; siC: Control siRNA; siM: MDR1 siRNA