Figure 5.

Functionality of nanolipoparticles containing MDR1 siRNA (NLP siM) and OFA siM in mice. 48 hr after systemic administration of formulated NLP siRNAs (0.8 and 1.6 mg/kg siM; 1.6 mg/kg siC) and OFA siM (1.6 mg/kg), tumor tissues harvested and total RNA was extracted for real-time RT-PCR analysis. The mRNA levels are shown relative to the control group (NS). The mRNA levels of MDR1 gene were normalized to the β-actin mRNA. Eeach group contained 3 mice and the reactions were performed in duplicate. The values are means ± SEM (*P<0.05, ** P<0.01, *** P<0.001)

NLP: Nanolipoparticle; siC: Control siRNA; siM: MDR1 siRNA; NS: Normal saline