Table 1.
Baseline traits and BMD measurements of participants (iTRAQ and validation groups).
| Parameter | Premenopausal women | Postmenopausal women | ||||
|---|---|---|---|---|---|---|
| Low BMD (n = 10) | High BMD (n = 10) | P value | Low BMD (n = 10) | High BMD (n = 10) | P value | |
| iTRAQ group | ||||||
| Age (years) | 36.1 ± 1.2 | 36 ± 1.1 | ns | 55.7 ± 1.1 | 53.8 ± 0.8 | ns |
| BMI (Kg/m2) | 24.7 ± 0.9 | 26.3 ± 0.6 | ns | 26.3 ± 0.8 | 28.5 ± 1.1 | ns |
| BMD at hip (g/cm2) | 0.796 ± 0.02 | 1.07 ± 0.01 | <0.0001 | 0.699 ± 0.02 | 1.008 ± 0.02 | <0.0001 |
| BMD at spine (g/cm2) | 0.980 ± 0.05 | 1.247 ± 0.03 | <0.0001 | 0.796 ± 0.03 | 1.154 ± 0.02 | <0.0001 |
| T score hip | −1.5 ± 0.13 | 0.76 ± 0.09 | <0.0001 | −2.33 ± 0.14 | 0.23 ± 0.17 | <0.0001 |
| T score spine | −1.66 ± 0.12 | 0.57 ± 0.24 | <0.0001 | −3.2 ± 0.22 | −0.16 ± 0.18 | <0.0001 |
| OPP/OP/N | OP = 10 | N = 10 | — | OPP = 9, OP = 1 | N = 10 | — |
|
| ||||||
| Validation group | ||||||
| Age (years) | 35.7 ± 0.8 | 34.8 ± 1.2 | ns | 54.2 ± 0.9 | 53.6 ± 0.9 | ns |
| BMI (Kg/m2) | 23.8 ± 0.9 | 25.6 ± 1.2 | ns | 24.9 ± 0.9 | 25.3 ± 0.5 | ns |
| BMD at hip (g/cm2) | 0.805 ± 0.01 | 1.075 ± 0.02 | <0.0001 | 0.707 ± 0.02 | 1.053 ± 0.02 | <0.0001 |
| BMD at spine (g/cm2) | 1.063 ± 0.04 | 1.219 ± 0.03 | 0.0029 | 0.840 ± 0.02 | 1.189 ± 0.03 | <0.0001 |
| T score hip | −1.5 ± 0.11 | 0.79 ± 0.16 | <0.0001 | −2.21 ± 0.22 | 0.61 ± 0.15 | <0.0001 |
| T score spine | −0.97 ± 0.24 | 0.31 ± 0.23 | 0.0033 | −2.84 ± 0.20 | 0.08 ± 0.23 | <0.0001 |
| OPP/OP/N | OP = 10 | N = 10 | — | OPP = 8, OP = 2 | N = 10 | — |
Values are mean ± SEM, ns is not significant, BMD is Bone Mineral Density, BMI is Body Mass Index, OPP stands for osteoporosis, OP stands for osteopenia, and N stands for normal.