Table 5.
Comparison of gentamicin-induced hair cell gene expression changes with gentamicin-induced expression changes in kidney.
| Gene symbol | Function Annotation | p-value in HC dataset | Fold Change in HC dataset | Findings in nephrotoxicity | Consistent |
|---|---|---|---|---|---|
| Ppp1r10 | Phosphatase | 5.84E-06 | 4.524746 | Upregulates | Yes |
| Ddit3 | Transcription factor | 2.62E-05 | 2.751878 | Upregulates | Yes |
| Jun | Transcription factor | 0.00245 | 2.732988 | Upregulates | Yes |
| Ccnl1 | RNA splicing | 4.46E-06 | 2.482795 | Upregulates | Yes |
| Gnl3 | p53 pathway regulation | 7E-06 | 2.127794 | Upregulates | Yes |
| Chka | Phospholipid synthesis | 6.28E-07 | 2.029311 | Upregulates | Yes |
| Ddx39 | RNA splicing | 4.98E-06 | 1.991224 | Upregulates | Yes |
| Nop58 | Ribosome biogenesis | 7.68E-08 | 1.941254 | Upregulates | Yes |
| Ppp1r15a | Phosphatase | 0.009454 | 1.739694 | Upregulates | Yes |
| Kti12 | Unkown | 0.008232 | 1.649551 | Upregulates | Yes |
| Ptbp1 | RNA splicing | 3.83E-05 | 1.636352 | Upregulates | Yes |
| Eed | Transcription repressor | 8.35E-06 | 1.601639 | Upregulates | Yes |
| Eif2b2 | Translation | 3.21E-06 | 1.572336 | Upregulates | Yes |
| Cul2 | Ubiquitin ligase | 7.77E-06 | 1.510931 | Upregulates | Yes |
| Zfp622 | Transcription regulator | 4.77E-06 | 1.483148 | Upregulates | Yes |
| Naa15 | N-acetyltransferase | 0.000102 | 1.461136 | Upregulates | Yes |
| Smn1 | RNA splicing | 0.000161 | 1.45206 | Upregulates | Yes |
| Phax | RNA export | 0.006074 | 1.438425 | Upregulates | Yes |
| Lig4 | DNA repair | 5.82E-05 | 1.41918 | Upregulates | Yes |
| Azin1 | Metabolism | 0.001597 | 1.388636 | Upregulates | Yes |
| Arf6 | Ras superfamily | 0.000976 | 1.388019 | Upregulates | Yes |
| 2310044G17Rik | Unkown | 0.005972 | 1.37605 | Upregulates | Yes |
| Eaf1 | Transcription factor | 0.000222 | 1.369313 | Upregulates | Yes |
| Cdk13 | Transcription elongation | 0.000244 | 1.365288 | Upregulates | Yes |
| Pafah1b1 | Inactivates platelet-act. factor | 0.000164 | 1.346669 | Upregulates | Yes |
| Gfer | Growth factor | 0.001933 | 1.324081 | Upregulates | Yes |
| Pelo | Mitosis | 0.000148 | 1.319478 | Upregulates | Yes |
| Tsc22d1 | Transcription regulator | 0.000157 | 1.315102 | Upregulates | Yes |
| Ddx50 | RNA helicase | 0.00147 | 1.313465 | Upregulates | Yes |
| Gadd45a | MAPK pathway regulator | 0.007003 | 1.30902 | Upregulates | Yes |
| Tars | tRNA synthesis | 0.001263 | 1.292011 | Upregulates | Yes |
| Mdm2 | p53 pathway regulation | 0.005424 | 1.28435 | Upregulates | Yes |
| Dnaja2 | Chaperone | 0.001429 | 1.282581 | Upregulates | Yes |
| Eif2b4 | Translation | 0.001361 | 1.270756 | Upregulates | Yes |
| Sfpq | RNA splicing | 0.000749 | 1.252767 | Upregulates | Yes |
| Cnksr3 | Sodium transport | 0.00051 | 1.240931 | Upregulates | Yes |
| Cand1 | Ubiquitin ligase | 0.003349 | 1.215329 | Upregulates | Yes |
| Mybbp1a | Transcription regulator | 0.000956 | 1.214954 | Upregulates | Yes |
| Ncl | Ribosome biogenesis | 0.00327 | 1.206809 | Upregulates | Yes |
| Decr2 | Metabolism | 0.003445 | −1.21269 | Downregulates | Yes |
| Asl | Urea cycle | 0.000314 | −1.27227 | Downregulates | Yes |
| Acsl3 | Metabolism | 0.000638 | −1.27564 | Downregulates | Yes |
| Gstm1 | Antioxidant | 0.00249 | −1.32453 | Downregulates | Yes |
| S100a1 | Calcium binding | 0.006299 | −1.37041 | Downregulates | Yes |
| Abat | Metabolism | 0.002967 | −1.38497 | Downregulates | Yes |
| Mrpl23 | Mitochondrial ribosome | 0.003565 | −1.38508 | Downregulates | Yes |
| Hacl1 | Metabolism | 0.002033 | −1.43919 | Downregulates | Yes |
| St6galnac3 | Glycolipid synthesis | 0.005244 | −1.46649 | Downregulates | Yes |
| Pcx | Metabolism | 0.00279 | −1.65712 | Downregulates | Yes |
| Eef1a1 | Translation | 2.35E-05 | −2.0177 | Downregulates | Yes |
| Zfp354a | Unkown | 0.001648 | 1.544937 | Downregulates | No |
| Hyou1 | Stress | 0.002956 | −1.22211 | Upregulates | No |
| Nedd4 | Ubiquitin ligase | 2.45E-06 | −1.27335 | Upregulates | No |
| Ctsd | Protease | 0.00174 | −1.33383 | Upregulates | No |
| Hspa5 | Stress | 0.004463 | −1.3884 | Upregulates | No |
| Calr | Calcium binding | 0.000413 | −1.4266 | Upregulates | No |
| Hsp90b1 | Chaperone | 5.87E-05 | −1.56328 | Upregulates | No |
| Egr1 | Transcription regulator | 0.004467 | −1.61013 | Upregulates | No |
| Zfp36l1 | Growth factor response | 0.001571 | −1.65211 | Upregulates | No |
| Pdia4 | Protein folding | 0.002689 | −1.72559 | Upregulates | No |
| Tubb5 | Cytoskeleton | 0.001836 | −2.0123 | Upregulates | No |
| Spp1 | Cell-matrix interaction | 0.004118 | −4.30391 | Upregulates | No |