Table 1.
Diet | Glucose concentration (mmol/L) |
v2 (pmol/islet/h) |
vnet (pmol/islet/h) |
v2/vnet (%) |
|||
---|---|---|---|---|---|---|---|
WT | G6pc2 KO | WT | G6pc2 KO | WT | G6pc2 KO | ||
CF | 5 | 2.7 ± 0.4 (4)A | 0.1 ± 0.3 (4) | 18 ± 1 (4)A | 14 ± 3 (4)A | 16 ± 4 (4)A | 2 ± 2 (4) |
HFF | 5 | 3.1 ± 0.1 (5)A | 0.1 ± 0.3 (5) | 14 ± 2 (5)A | 14 ± 3 (5)A | 25 ± 3 (5)A/B | 0.5 ± 2 (5) |
CF | 11 | 11 ± 1 (5)B | 0.9 ± 0.3 (4) | 28 ± 4 (5)A/B | 31 ± 5 (4)A/B | 40 ± 6 (5)B | 3 ± 1 (4) |
HFF | 11 | 14 ± 1 (7)B | 1.2 ± 0.4 (7) | 45 ± 8 (7)B | 46 ± 9 (7)B | 35 ± 5 (7)B | 3 ± 1 (7) |
Rate of v2, vnet, and v2/vnet results are reported as the mean ± SEM (number of incubations). In each column, groups were compared by ANOVA. If at least one mean value was significantly different, pairwise comparisons were performed by Tukey-Kramer test. Statistically separated groups are indicated by different letters (A and B).