Table 1.
Metabolic features of mice analyzed in this study
| Feeding status |
Control mice
(n ≥ 9) |
DBD-het mice
(n ≥ 7) |
L-FoxO1 mice
(n ≥ 10) |
L-DBD mice
(n ≥ 7) |
|
|---|---|---|---|---|---|
| Chow | |||||
| Body weight (g) | Fed | 25.6 ± 0.6 | 25.2 ± 0.4 | 25.1 ± 0.8 | 24.2 ± 0.8 |
| Lean mass (%) | Fed | 80.2 ± 0.6 | 78.8 ± 1.2 | 80.3 ± 1.2 | 81.4 ± 0.2 |
| Fat mass (%) | Fed | 12.0 ± 0.6 | 13.2 ± 0.3 | 11.8 ± 1.2 | 10.5 ± 0.4 |
| Fluid mass (%) | Fed | 7.7 ± 0.3 | 8.0 ± 0.1 | 7.8 ± 0.2 | 8.1 ± 0.3 |
| FFAs (mEq/L) | Fasted | 1.09 ± 0.19 | 0.88 ± 0.08 | 1.23 ± 0.09 | 1.14 ± 0.13 |
| Refed | 0.19 ± 0.02 | 0.21 ± 0.03 | 0.20 ± 0.03 | 0.21 ± 0.03 | |
| TGs (mg/dL) | Fasted | 76 ± 6 | 67 ± 3 | 84 ± 4 | 72 ± 12 |
| Refed | 102 ± 11 | 106 ± 11 | 92 ± 7 | 121 ± 9 | |
| Cholesterol (mg/dL) | Fasted | 92 ± 4 | 98 ± 4 | 102 ± 5 | 96 ± 6 |
| Refed | 92 ± 3 | 84 ± 4 | 85 ± 4 | 90 ± 3 | |
| Liver cholesterol (mg/g liver) | Fasted | 1.66 ± 0.16 | 1.94 ± 0.17 | 1.56 ± 0.13 | 1.75 ± 0.11 |
| Refed | 1.17 ± 0.10 | ND | 1.10 ± 0.07 | 1.12 ± 0.13 | |
| WTD | |||||
| Body weight (g) | Fed | 33.2 ± 1.2 | 34.9 ± 1.8 | 38.0 ± 1.0 | 36.0 ± 2.8 |
| Glucose (mg/dL) | Fed | 218 ± 3 | 223 ± 2 | 190 ± 4 | 203 ± 7 |
| Fasted | 241 ± 14 | 242 ± 10 | 214 ± 7 | 220 ± 9 | |
| Insulin (ng/mL) | Fed | 2.87 ± 0.22 | 2.43 ± 0.55 | 4.22 ± 0.95 | 6.66 ± 3.15 |
| Fasted | 2.58 ± 0.30 | 2.11 ± 0.27 | 2.68 ± 0.32 | 2.25 ± 0.42 | |
| FFAs (mEq/L) | Fed | 0.76 ± 0.04 | 0.72 ± 0.08 | 0.71 ± 0.05 | 0.79 ± 0.06 |
| Fasted | 0.71 ± 0.06 | 0.70 ± 0.05 | 0.74 ± 0.05 | 0.71 ± 0.07 | |
| TGs (mg/dL) | Fed | 113 ± 11 | 118 ± 12 | 104 ± 7 | 118 ± 7 |
| Fasted | 59 ± 6 | 67 ± 6 | 53 ± 3 | 63 ± 9 | |
| Cholesterol (mg/dL) | Fed | 296 ± 21 | 344 ± 27 | 364 ± 28 | 428 ± 42 |
| Fasted | 337 ± 34 | 342 ± 27 | 398 ± 31 |
Data are reported as the mean ± SEM. None of the differences between genotypes reach statistical significance by Tukey post hoc test after one-way ANOVA. ND, not determined.