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. 2015 Jan 9;64(6):2220–2233. doi: 10.2337/db14-1397

Figure 2.

Figure 2

A: Age-matched BAMBI+/+ and BAMBI−/− mice were injected with STZ as described in research design and methods. Both groups developed comparable degrees of hyperglycemia when compared with citrate-injected controls during the 18-week study period (n = 5 for BAMBI+/+ citrate-injected mice; n = 7 for BAMBI−/− citrate-injected mice; n = 7 for BAMBI+/+ STZ-induced diabetic mice; and n = 8 for BAMBI−/− STZ-induced diabetic mice). *P < 0.05 compared with citrate-injected controls. B: BAMBI−/− mice tended to weigh less than BAMBI+/+ littermates at the time of citrate or STZ injection, and both diabetic BAMBI+/+ and BAMBI−/− mice gained significantly less weight compared with nondiabetic (e.g., citrate-injected) BAMBI+/+ and BAMBI−/− control mice during the 18-week study period. C: After 18 weeks of diabetes, the urinary albumin-to-creatinine ratio (UACR) of diabetic BAMBI+/+ mice was significantly, but only modestly, elevated compared with that of nondiabetic BAMBI+/+ mice; it was, however, more than twice as elevated in diabetic BAMBI−/− mice. *P < 0.05 compared with the respective citrate-injected controls; #P < 0.05 compared with the respective BAMBI+/+ STZ-injected mice.