Figure 4.
Effects of DPP-4 inhibition on hepatic de novo lipogenesis markers and hepatic TAG secretion. Values are means ± SE. Hepatic mRNA expression for ACC, FAS and SREBF (A), protein content for ACC, FAS and SREBP-1c (B), hepatic TAG secretion time course (C) and rate (D), mRNA expression for MTTP and apoB (E), and protein content for MTTP and apoB100 (F). n = 8–10 per group for gene expression and protein content. n = 6–7 per group for TAG secretion studies. *P < 0.01, main effect of diet. &P < 0.05 for interaction (significantly different than CD). $P < 0.05 for interaction (significantly different than WD).