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. 2015 Jan 20;64(6):1988–2001. doi: 10.2337/db14-0804

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© 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

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Mechanistic schematic of DPP-4 inhibition with MK0626 on hepatic metabolism and hepatic insulin resistance. Improvement in hepatic insulin resistance by DPP-4 inhibitor MK0626 (1) resulted from decreased levels of DAG and TAG (2), increasing hepatic TAG secretion (3), enhancing select genes and proteins involved in mitochondrial content and function (4), suppressing incomplete oxidation of fatty acids (5), enhancing utilization of metabolites through enhanced PDH activity (6) and TCA cycle flux (6), presumably decreasing carbon intermediates available of lipogenesis and lowering uric acid levels (7) and thereby suppressing the lipogenic effects of uric acid.