Table 1.
Animal, liver, and plasma characteristics
| CD | CD-MK | WD | WD-MK | |
|---|---|---|---|---|
| Body weight (g) | 27.5 ± 0.6 | 27.7 ± 0.7 | 39.0 ± 1.4* | 37.2 ± 1.4* |
| Liver weight (g) | 1.14 ± 0.04 | 1.02 ± 0.05# | 1.46 ± 0.08* | 1.16 ± 0.04*# |
| Fat pad mass (g) | 0.76 ± 0.09 | 0.84 ± 0.11 | 2.80 ± 0.14* | 2.52 ± 0.21* |
| Body fat (%) | 14.5 ± 2.2 | 17.7 ± 0.6 | 35.1 ± 0.8* | 36.7 ± 1.7* |
| Food intake (kcal/week) | 84.0 ± 3.4 | 81.7 ± 4.9 | 89.7 ± 3.6* | 95.2 ± 5.1* |
| Plasma ALT (units/L) | 12.3 ± 1.0 | 14.2 ± 0.8 | 22.4 ± 2.8* | 18.3 ± 1.9* |
| Plasma total cholesterol (mg/dL) | 112.9 ± 7.4 | 111.9 ± 7.0 | 137.7 ± 8.1* | 126.1 ± 7.8* |
| Plasma triglycerides (mg/dL) | 54.1 ± 3.1 | 59.6 ± 4.4# | 61.1 ± 5.3 | 67.9 ± 3.8# |
| Plasma NEFA (nmol/L) | 0.70 ± 0.06 | 0.70 ± 0.08 | 0.83 ± 0.08 | 0.76 ± 0.07 |
| Plasma uric acid (mg/dL) | 0.45 ± 0.04 | 0.40 ± 0.03# | 0.72 ± 0.08* | 0.49 ± 0.04*# |
| Liver DPP-4 activity (RLUs) | 28,391 ± 1,551 | 9,729 ± 1,362# | 27,567 ± 1,931 | 7,336 ± 679# |
Values are means ± SE. n = 8–12 per group except n = 6–7 per group for percent body fat and n = 6–8 per group for food intake. Fat pad mass is the sum of epididymal and retroperitoneal fat pads. RLUs, relative light units.
*P < 0.05, main effect of diet.
#P < 0.05, main effect of MK compound.