Table 3.
Baseline | 6 months | 12 months | |
---|---|---|---|
MMSE | |||
Donepezil | 21.0±3.9 | 22.0±3.3* | 21.3±4.3 |
Rivastigmine | 21.0±3.5 | 22.6±3.2 | 21.1±3.6 |
Galantamine | 20.8±3.7 | 21.6±3.3 | 18.9±3.7 |
ADAS-cog | |||
Donepezil | 18.2±8.1 | 16.6±5.9 | 16.5±8.0 |
Rivastigmine | 16.9±4.6 | 17.2±3.8 | 16.5±4.1 |
Galantamine | 15.5±5.4 | 16.6±6.9 | 18.6±7.2 |
TMT-Part A | |||
Donepezil | 107.5±35.9 | 86.5±34.4# | 89.9±36.8 |
Rivastigmine | 95.3±33.5 | 98.2±35.2 | 80.7±28.7 |
Galantamine | 88.8±37.5 | 100.3±42.1 | 85.6±48.3 |
NPI | |||
Donepezil | 4.2±2.8 | 3.9±2.7 | 3.5±3.0 |
Rivastigmine | 4.3±4.5 | 3.6±2.8 | 4.0±3.9 |
Galantamine | 4.8±3.1 | 3.7±2.2 | 4.8±3.6 |
FAQ | |||
Donepezil | 13.4±8.1 | 14.4±6.3 | 12.6±7.3 |
Rivastigmine | 12.9±6.2 | 13.6±4.5 | 13.4±4.2 |
Galantamine | 12.3±6.7 | 13.4±6.3 | 15.9±7.6† |
p < 0.05
p < 0.01, improvement versus baseline
p < 0.01, worsening versus baseline.