Table 2.

Frequency of malignant transformation of hepatocellular adenoma: Number of reported cases by decade from reports including at least 20 resected cases

Reference (first author)	Publication year	Patients with adenoma			HCC within adenoma number of patients
		total	resected	sex ratio
Kerlin [14]	1983	23	17	21/2	2
Mathieu [15]	1986	27	27	27/0	0
Leese [16]	1988	24	17	16/8	1
Total		74	61		3 (5%)
Arrive [17]	1994	29	21	27/2	01
Foster [18]	1994	50	37	NA	12
Nagorney [19]	1995	24	19	22/2	1
Weimann [20]	1997	44	39	39/4	2
Total		136	116		4 (4%)
Ichikawa [21]	2000	25	14	21/4	2
Reddy [22]	2001	25	25	25/0	1
Terkivatan [23]	2001	33	19	29/4	0
Toso [24]	2005	25	25	23/2	2
Van der Windt [25]	2006	48	16	48/0	2
Cho [26]	2008	41	41	38/3	2
Deneve [27]	2009	124	119	116/8	5
Bioulac-Sage [11]	2009	128	128	116/12	6
Dokmak [12]	2009	122	122	108/14	10
Total		530	509		30 (6%)

¹Dysplasia was present in 3 patients.

²Hepatocholangiocarcinoma. Reproduced with permission from Farges O, et al.[20].