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. 2015 Mar 24;172(11):2675–2700. doi: 10.1111/bph.13096

Figure 5.

Figure 5

Clinically relevant resistance mutations of MEK1, ABL1 and ALK. (A) MEK1 and MEK2 mapped onto pdb 3eqc. The majority of the mutations cluster at the interface with the autoinhibitory N-terminal helix (top left in this view). (B) ABL mapped onto pdb 1iep. The imatinib-resistant mutants are spread all over the kinase domain; however, the most resistant against imatinib is the gatekeeper mutant T315I in the hinge (green) and the mutations located in the P-loop (red). (C) ALK mapped onto pdb 2xp2. Crizotinib-resistant mutations. The most resistant mutation is L1196M in the hinge (green) region.