Table 1.
List of interactions between miRNA and drug metabolism-related genes
| Gene ID | Function | Interacting miRNA | References |
|---|---|---|---|
| CYP1A1 | Phase I enzyme | miR-18b, -20b | Wang et al., 2009; Glubb and Innocenti, 2011 |
| CYP1B1 | Phase I enzyme | miR-27b | Tsuchiya et al., 2006; Chuturgoon et al., 2014 |
| CYP2A3 | Phase I enzyme | miR-126*, -34 | Kalscheuer et al., 2008 |
| CYP2E1 | Phase I enzyme | miR-378 | Mohri et al., 2010; Takahashi et al., 2014 |
| CYP2J2 | Phase I enzyme | Let-7b | F Chen et al., 2012a |
| CYP3A4 | Phase I enzyme | miR-27b, -577, -1, -532-3p, -627, -223, -148 | Takagi et al., 2008; Pan et al., 2009a; Takahashi et al., 2014; Wei et al., 2014 |
| CYP7A1 | Phase I enzyme | miR-122a, miR-422a | Song et al., 2010 |
| CYP19A1 | Phase I enzyme | miR-19b, -106a, let-7f | Shibahara et al., 2012; Kumar et al., 2013 |
| CYP24A1 | Phase I enzyme | miR-125b | Komagata et al., 2009 |
| GSS | Phase I enzyme | miR-125b | Tili et al., 2012 |
| GPX7 | Phase I enzyme | miR-122 | Akinc et al., 2008 |
| SULF1 | Phase I Enzyme | miR-516a | Takei et al., 2011 |
| GSTP1 | Phase II enzyme | miR-133a, -513a-3p | Zhang et al., 2012; Uchida et al., 2013 |
| SULT1A1 | Phase II enzyme | miR-631 | Yu et al., 2010 |
| UGT1A | Phase II enzyme | miR-491-3p | Dluzen et al., 2014 |
| ABCA1 | Transporter | miR-33, -33*, -758, -106b, -613, -27a, -27b, -145, -101, -135b | Ramirez et al., 2011; Borel et al., 2012; Kim et al., 2012; Goedeke et al., 2013; Kang et al., 2013; Rottiers et al., 2013; Zhang et al., 2014; Zhao et al., 2014 |
| ABCB1/P-gp/MDR1 | Transporter | miR-451, -27a, -298, -354, -7, -200c, -19a/b | Kovalchuk et al., 2008; Zhu et al., 2008; Pogribny et al., 2010; Bitarte et al., 2011; Bao et al., 2012; J Chen et al., 2012b; F Wang et al., 2013a |
| ABCB11 | Transporter | miR-33 | Allen et al., 2012 |
| ABCC1/MRP-1 | Transporter | miR-134, -326, -1291, -199a/b, -296 | Guo et al., 2010; Liang et al., 2010; Borel et al., 2012; Pan et al., 2013 |
| ABCC2 | Transporter | miR-379, let-7c | Haenisch et al., 2011; Zhan et al., 2013 |
| ABCC3 | Transporter | miR-9* | Jeon et al., 2011 |
| ABCC4/MRP4 | Transporter | miR-124a, -506, -125a/b | Borel et al., 2012; Markova and Kroetz, 2014 |
| ABCC5 | Transporter | miR-128 | Zhu et al., 2011 |
| ABCC6 | Transporter | miR-9* | Jeon et al., 2011 |
| ABCC7/CFTR | Transporter | miR-145, -494, -1246, -509-3p | Gillen et al., 2011; Ramachandran et al., 2013 |
| ABCC10 | Transporter | Let-7a/e | Borel et al., 2012 |
| ABCE1 | Transporter | miR-124, -203, -26a, -135b, -145 | Furuta et al., 2010; Borel et al., 2012 |
| ABCG1 | Transporter | miR-33 | Marquart et al., 2010; Rayner et al., 2010 |
| ABCG2/BCRP | Transporter | miR-520h, -519c, -328, -487a, -181a | Liao et al., 2008; Pan et al., 2009b; To et al., 2009; Wang et al., 2010; Li et al., 2011; Padmanabhan et al., 2012; Jiao et al., 2013; Ma et al., 2013 |
| SLC6A4 | Transporter | miR-16, -15a | Baudry et al., 2010; Tamarapu Parthasarathy et al., 2012; Moya et al., 2013 |
| SLC7A5 | Transporter | miR-126 | Miko et al., 2011 |
| SLC7A11 | Transporter | miR-27a | Drayton et al., 2014 |
| SLC15A1/PEPT1 | Transporter | miR-92a | Dalmasso et al., 2011b |
| SLC12A2 | Transporter | miR-384, -494, -1246 | Gillen et al., 2011 |
| SLC16A1/MCT1 | Transporter | miR-124, -29a/b | KK Li et al., 2009b; Pullen et al., 2011 |
| NR1I2/PX receptor | Nuclear Receptor | miR-148a | Takagi et al., 2008 |
| NR3C1/GR | Nuclear Receptor | miR-18, -124a | Vreugdenhil et al., 2009 |
| NR2B1/RXRA | Nuclear Receptor | miR-27a, -27b | Ji et al., 2009; Komagata et al., 2009; Mohri et al., 2009 |
| NR1I1/VD receptor | Nuclear Receptor | miR-27b, -125b | Mohri et al., 2009; Pan et al., 2009a |
| NR1C1 | Nuclear Receptor | miR-10b, -506, -21, -27b | Zheng et al., 2010; Kida et al., 2011; Tong et al., 2011; Zhou et al., 2011 |
| NR1C3 | Nuclear Receptor | miR-130, -27b, -27a | Jennewein et al., 2010; Kim et al., 2010; Lee et al., 2012 |
| NR1C2 | Nuclear Receptor | miR-15a, -199a, -214, -9 | Yin et al., 2010; el Azzouzi et al., 2013; Thulin et al., 2013 |
| NR1H3/LXRA | Nuclear Receptor | miR-613, -206, -1 | Ou et al., 2011; Zhong et al., 2013; Vinod et al., 2014 |
| NR2A1/HNF4A | Nuclear Receptor | miR-24, -34a | Takagi et al., 2010 |
| NR3A1 | Nuclear Receptor | miR-221, -222, let-7a, miR-130a, -22, -206 | Iorio et al., 2005; Adams et al., 2007; Zhao et al., 2008; 2011b,; Pandey and Picard, 2009; Xiong et al., 2010; Tang et al., 2011 |
| RXRA | Modifier | miR-27a/b | Ji et al., 2009 |