Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat

. 2015 May 12;172(11):2799–2813. doi: 10.1111/bph.12974

TARGETS
Ligand-gated ion channel^a	Transporters^c
NMDA receptors	MRP, multidrug resistance protein, ABCC1
Enzymes^b	P-gp, P-glycoprotein, ABCB1
CYP2B6
CYP3A4

LIGANDS
Ketamine
Morphine
Normorphine

These Tables list key protein targets and ligands in this article which are hyperlinked to corresponding entries in http://www.guidetopharmacology.org, the common portal for data from the IUPHAR/BPS Guide to PHARMACOLOGY (Pawson et al., 2014) and are permanently archived in the Concise Guideto PHARMACOLOGY 2013/14 (^a,b,cAlexander et al., 2013a,b,c).