. 2015 Apr 23;172(11):2814–2826. doi: 10.1111/bph.13075

Table 4.

The in vivo effects of ENaC blockers on guinea pig TPD and blood potassium levels following i.t. dosing

Compound	ED₅₀ (μg·kg⁻¹)		Max non-hyperkalaemic dose (μg·kg⁻¹)^a
Compound	1 h	4 h	Max non-hyperkalaemic dose (μg·kg⁻¹)^a
Amiloride	16^b	>5000	500
NVP-QBE170	1.7	410	≥2000
P552-02	0.2^b	128	<60

The effects of ENaC blockers were evaluated for effects on the TPD in guinea pigs both at 1 and 4 h after i.t. instillation of a solution dose. Each study comprised group sizes of 4–10 animals within each treatment group. ^aIndicates the highest dose level that failed to induce a significant rise in blood K⁺ levels above the vehicle control group. ^bIndicates data previously reported in Coote et al. (2008).