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. 2015 Mar 26;172(11):2878–2891. doi: 10.1111/bph.13093

Figure 2.

Figure 2

Effect of dofetilide (1 mg·kg−1, p.o.) on QT interval and short-term QT interval variability in cynomolgus monkeys. (A) Dofetilide-induced QT prolongation. (B) Dofetilide also caused a marked increase in STVQT. (C) Power spectral analysis reveals QT interval HF (>0.1 Hz) rhythmic oscillations in dofetilide treated animals. (D) amplitude of QT interval HF oscillations. The time course of changes in QT interval HF rhythmic oscillations fits with those of STVQT. Data are presented as mean values ± SEM; n = 6. *P ≤ 0.05, **P ≤ 0.01, significantly different from vehicle.