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Effects of dofetilide (1 mg·kg−1, p.o.) on HR and short-term HR variability in cynomolgus monkeys. (A) Dofetilide was quite devoid of effect on mean HR. (B) In parallel, dofetilide increased beat-to-beat STVHR. (C) Power spectral analysis of HR variability reveals HF (>0.1 Hz) rhythmic oscillations of HR in dofetilide-treated animals. (D) Amplitude of HR HF oscillations. Data are presented as mean values ± SEM; n = 6. *P ≤ 0.05, **P ≤ 0.01, significantly different from vehicle.
