Table 1.
Differential expressed miRNAs between tumor and paired adjacent normal mucosa in different stages
| miRNAs | II-III | II | III | stages with significant change (P<0.05) | |||
|---|---|---|---|---|---|---|---|
|
| |||||||
| fold change | P Value | fold change | P Value | fold change | P Value | ||
| hsa-miR-1 | -16.393 | <0.001 | -17.544 | 0.009 | -15.152 | 0.014 | II, III, II-III |
| hsa-miR-145 | -15.873 | <0.001 | -18.182 | 0.001 | -13.699 | <0.001 | II, III, II-III |
| hsa-miR-145* | -13.158 | <0.001 | -9.615 | <0.001 | -18.868 | <0.001 | II, III, II-III |
| hsa-miR-137 | -10.870 | <0.001 | -13.514 | 0.001 | -8.403 | 0.016 | II, III, II-III |
| hsa-miR-363 | -6.993 | 0.001 | -6.993 | 0.028 | -6.993 | 0.006 | II, III, II-III |
| hsa-miR-143 | -6.944 | <0.001 | -7.407 | 0.022 | -6.452 | 0.005 | II, III, II-III |
| hsa-miR-4770 | -6.803 | <0.001 | -8.333 | 0.001 | -5.263 | 0.022 | II, III, II-III |
| hsa-miR-490-5p | -6.536 | <0.001 | -6.993 | 0.007 | -6.098 | 0.021 | II, III, II-III |
| hsa-miR-9 | -5.848 | <0.001 | -6.494 | 0.014 | -5.208 | 0.014 | II, III, II-III |
| hsa-miR-144* | -5.435 | <0.001 | -3.788 | 0.044 | -8.264 | 0.001 | II, III, II-III |
| hsa-miR-99a | -4.975 | 0.001 | -6.369 | 0.013 | -3.745 | 0.025 | II, III, II-III |
| hsa-miR-99b | -4.739 | <0.001 | -5.556 | 0.010 | -3.953 | 0.004 | II, III, II-III |
| hsa-miR-23b | -4.717 | <0.001 | -3.559 | 0.044 | -6.536 | 0.001 | II, III, II-III |
| hsa-miR-143* | -4.505 | <0.001 | -4.505 | 0.008 | -4.484 | 0.026 | II, III, II-III |
| hsa-miR-100 | -4.386 | 0.002 | -5.495 | 0.022 | -3.356 | 0.047 | II, III, II-III |
| hsa-miR-768-3p | -4.367 | <0.001 | -4.049 | 0.003 | -4.785 | 0.001 | II, III, II-III |
| hsa-miR-24-1* | -4.202 | <0.001 | -2.924 | 0.050 | -6.369 | <0.001 | II, III, II-III |
| hsa-miR-125a-5p | -4.065 | 0.001 | -5.000 | 0.018 | -3.185 | 0.019 | II, III, II-III |
| hsa-miR-30e* | -3.774 | <0.001 | -3.322 | 0.013 | -4.367 | 0.001 | II, III, II-III |
| hsa-miR-574-3p | -3.289 | <0.001 | -2.874 | 0.033 | -3.846 | 0.004 | II, III, II-III |
| hsa-miR-126 | -3.279 | 0.001 | -3.257 | 0.012 | -3.311 | 0.050 | II, III, II-III |
| hsa-let-7b | -3.215 | 0.001 | -3.704 | 0.011 | -2.732 | 0.041 | II, III, II-III |
| hsa-miR-1979 | -2.915 | 0.003 | -2.092 | 0.045 | -4.274 | 0.018 | II, III, II-III |
| hsa-miR-374b | -2.703 | 0.002 | -2.519 | 0.018 | -2.924 | 0.049 | II, III, II-III |
| hsa-miR-140-3p | -2.381 | 0.002 | -2.381 | 0.040 | -2.381 | 0.014 | II, III, II-III |
| hsa-miR-203 | 2.449 | 0.026 | 2.899 | 0.038 | 8.024 | 0.030 | II, III, II-III |
| hsa-miR-182 | 3.290 | 0.002 | 2.769 | 0.022 | 4.015 | 0.040 | II, III, II-III |
| hsa-miR-96 | 6.009 | <0.001 | 5.801 | 0.001 | 6.259 | 0.014 | II, III, II-III |
| hsa-miR-133a | -7.634 | 0.008 | -11.494 | 0.002 | -4.808 | 0.261 | II, II-III |
| hsa-miR-133b | -6.098 | 0.002 | -7.407 | 0.017 | -4.854 | 0.056 | II, II-III |
| hsa-miR-451 | -4.587 | 0.003 | -5.076 | 0.024 | -4.082 | 0.057 | II, II-III |
| hsa-miR-139-5p | -4.184 | 0.005 | -5.376 | 0.026 | -3.135 | 0.111 | II, II-III |
| hsa-miR-218 | -4.167 | 0.007 | -5.435 | 0.028 | -3.067 | 0.138 | II, II-III |
| hsa-miR-193a-5p | -3.472 | 0.002 | -3.788 | 0.013 | -3.155 | 0.065 | II, II-III |
| hsa-miR-365 | -3.472 | 0.002 | -3.717 | 0.010 | 1.239 | 0.786 | II, II-III |
| hsa-miR-204 | -3.344 | 0.004 | -3.509 | 0.039 | -3.165 | 0.056 | II, II-III |
| hsa-miR-328 | -3.311 | 0.009 | -4.831 | 0.012 | -2.137 | 0.285 | II, II-III |
| hsa-miR-193b | -3.257 | 0.009 | -3.861 | 0.048 | -2.681 | 0.094 | II, II-III |
| hsa-miR-3653 | -2.941 | 0.003 | -3.012 | 0.022 | -2.874 | 0.061 | II, II-III |
| hsa-miR-26a | -2.833 | 0.005 | -3.344 | 0.039 | -2.342 | 0.063 | II, II-III |
| hsa-miR-4799-5p | -2.732 | 0.049 | -3.846 | 0.043 | -1.779 | 0.483 | II, II-III |
| hsa-miR-10b | -2.299 | 0.007 | -2.710 | 0.039 | -1.898 | 0.091 | II, II-III |
| hsa-miR-150 | -1.832 | 0.025 | -2.551 | 0.011 | -1.252 | 0.584 | II, II-III |
| hsa-miR-429 | 2.475 | 0.013 | 2.602 | 0.045 | 2.335 | 0.147 | II, II-III |
| hsa-miR-592 | 2.550 | 0.040 | 5.060 | 0.017 | 4.604 | 0.090 | II, II-III |
| hsa-miR-141 | 2.948 | 0.049 | 5.858 | 0.016 | 1.335 | 0.718 | II, II-III |
| hsa-miR-183 | 3.291 | 0.006 | 3.092 | 0.048 | 3.537 | 0.068 | II, II-III |
| hsa-miR-135b | 4.189 | 0.002 | 6.154 | 0.004 | 2.688 | 0.174 | II, II-III |
| hsa-miR-4510 | -5.650 | 0.002 | -4.902 | 0.056 | -6.757 | 0.009 | III, II-III |
| hsa-let-7d | -5.376 | 0.005 | -2.632 | 0.101 | -12.195 | 0.022 | III, II-III |
| hsa-miR-3195 | -4.717 | 0.002 | -4.587 | 0.061 | -4.878 | 0.005 | III, II-III |
| hsa-let-7c | -4.566 | 0.001 | -2.882 | 0.072 | -7.752 | 0.004 | III, II-III |
| hsa-miR-4469 | -4.237 | 0.024 | -2.667 | 0.307 | -7.576 | 0.017 | III, II-III |
| hsa-miR-27b | -4.115 | 0.006 | -1.927 | 0.222 | -9.901 | 0.011 | III, II-III |
| hsa-miR-214 | -3.333 | 0.003 | -2.695 | 0.099 | -4.237 | 0.006 | III, II-III |
| hsa-miR-9* | -3.135 | 0.020 | -2.119 | 0.279 | -4.902 | 0.020 | III, II-III |
| hsa-miR-378i | -3.115 | 0.002 | -2.632 | 0.097 | -3.861 | 0.003 | III, II-III |
| hsa-let-7g | -3.040 | 0.003 | -2.160 | 0.117 | -4.505 | 0.014 | III, II-III |
| hsa-miR-378* | -2.994 | 0.001 | -2.469 | 0.095 | -3.745 | <0.001 | III, II-III |
| hsa-miR-199a-3p | -2.801 | 0.004 | -2.299 | 0.113 | -3.521 | 0.007 | III, II-III |
| hsa-miR-4684-3p | -2.717 | 0.015 | -2.959 | 0.112 | -2.451 | 0.028 | III, II-III |
| hsa-miR-4443 | -2.445 | 0.008 | -2.092 | 0.076 | -2.967 | 0.047 | III, II-III |
| hsa-miR-214* | -2.421 | 0.009 | -1.869 | 0.189 | -3.257 | 0.009 | III, II-III |
| hsa-miR-199b-3p | -2.364 | 0.012 | -2.309 | 0.107 | -2.427 | 0.048 | III, II-III |
| hsa-miR-422a | -2.364 | 0.014 | -1.821 | 0.201 | -3.185 | 0.029 | III, II-III |
| hsa-miR-26a-2* | -1.984 | 0.038 | -1.511 | 0.344 | -2.717 | 0.038 | III, II-III |
| hsa-miR-1290 | 3.324 | 0.023 | 4.955 | 0.058 | 8.347 | 0.038 | III, II-III |
| hsa-let-7d* | -3.344 | 0.020 | -2.770 | 0.132 | -4.149 | 0.056 | II-III |
| hsa-miR-378d | -3.788 | 0.043 | -3.831 | 0.134 | -3.731 | 0.184 | II-III |
| hsa-miR-4524* | -3.759 | 0.013 | -1.572 | 0.492 | -4.464 | 0.077 | II-III |
| hsa-miR-4423-3p | -3.650 | 0.019 | -2.793 | 0.135 | -5.128 | 0.065 | II-III |
| hsa-miR-151b | -3.571 | 0.021 | -3.509 | 0.122 | -3.650 | 0.093 | II-III |
| hsa-miR-28-5p | -3.165 | 0.004 | -2.967 | 0.051 | 1.168 | 0.843 | II-III |
| hsa-miR-30c-2* | -3.086 | 0.007 | -2.740 | 0.061 | -3.546 | 0.064 | II-III |
| hsa-miR-26b | -3.030 | 0.023 | -3.610 | 0.076 | -2.481 | 0.179 | II-III |
| hsa-miR-195 | -2.976 | 0.015 | -3.155 | 0.083 | -2.786 | 0.097 | II-III |
| hsa-miR-4526 | -2.950 | 0.032 | -2.933 | 0.151 | -2.976 | 0.092 | II-III |
| hsa-miR-30a | -2.857 | 0.031 | -3.030 | 0.134 | -2.674 | 0.120 | II-III |
| hsa-miR-29b-2* | -2.833 | 0.012 | -2.809 | 0.096 | -2.857 | 0.067 | II-III |
| hsa-miR-149 | -2.710 | 0.034 | -2.604 | 0.144 | -2.833 | 0.137 | II-III |
| hsa-miR-628-3p | -2.703 | 0.045 | -2.309 | 0.260 | 1.230 | 0.804 | II-III |
| hsa-miR-490-3p | -2.457 | 0.041 | -1.626 | 0.349 | -3.953 | 0.065 | II-III |
| hsa-miR-130a | -2.347 | 0.033 | -2.674 | 0.110 | -2.016 | 0.152 | II-III |
| hsa-miR-30c | -2.262 | 0.014 | -2.577 | 0.052 | -1.949 | 0.147 | II-III |
| hsa-miR-30d* | -2.212 | 0.034 | -2.114 | 0.126 | -2.331 | 0.157 | II-III |
| hsa-miR-10a | -2.083 | 0.023 | -2.227 | 0.111 | -1.927 | 0.113 | II-III |
| hsa-miR-27b* | -2.083 | 0.048 | -1.748 | 0.311 | -2.551 | 0.069 | II-III |
| hsa-miR-181c | -2.070 | 0.026 | -2.132 | 0.109 | -2.004 | 0.095 | II-III |
| hsa-miR-487b | -2.053 | 0.018 | -1.821 | 0.160 | -2.358 | 0.056 | II-III |
| hsa-miR-4790-5p | -2.020 | 0.027 | -1.645 | 0.112 | -2.604 | 0.123 | II-III |
| hsa-miR-338-3p | -1.961 | 0.041 | -2.375 | 0.051 | -1.575 | 0.371 | II-III |
| hsa-miR-708 | 1.937 | 0.036 | 1.806 | 0.133 | -1.036 | 0.968 | II-III |
| hsa-miR-503 | 1.984 | 0.036 | 2.258 | 0.072 | 1.708 | 0.278 | II-III |
| hsa-miR-21 | 1.997 | 0.040 | 1.985 | 0.171 | 2.010 | 0.125 | II-III |
| hsa-miR-130b | 2.153 | 0.022 | 1.811 | 0.110 | 2.629 | 0.108 | II-III |
| hsa-miR-200a | 2.383 | 0.022 | 2.527 | 0.112 | 2.228 | 0.110 | II-III |
| hsa-miR-4794 | -1.980 | 0.134 | -2.915 | 0.049 | -1.221 | 0.791 | II |
| hsa-miR-155 | -1.053 | 0.862 | -1.107 | 0.736 | 4.010 | 0.032 | III |
| hsa-miR-4489 | -2.252 | 0.078 | -1.389 | 0.599 | -4.115 | 0.040 | III |
| hsa-miR-4634 | -1.340 | 0.493 | 1.212 | 0.791 | -2.457 | 0.012 | III |
| hsa-miR-545 | 1.115 | 0.767 | -1.072 | 0.896 | 5.448 | 0.037 | III |
| hsa-miR-224 | 2.384 | 0.051 | 3.032 | 0.066 | 7.185 | 0.048 | III |
| hsa-miR-7 | 1.762 | 0.089 | 1.577 | 0.281 | 7.968 | 0.019 | III |