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Effect of the rs769217 polymorphism of the CAT gene on the transcription activity. Relative luciferase activity (RLA) was measured in HEK293 cells transfected with rs769217C or rs769217T plasmid constructs as described in methods. The fold increase of RLA was significantly higher in cells transfected with wild C allele than those transfected with variant T allele (*P = 0.004 < 0.05 for rs769217C vs. 769217T).
