Table 2.
Distribution of ABCB1 C3435T and G2677T/A polymorphisms and associations with risk of colorectal cancer
| Genotypes | Colorectal cancer patients N = 316 (%) | Control subjects N = 316 (%) | Adjusted OR (95% CI)1 | P value |
|---|---|---|---|---|
| ABCB1 C3435T | ||||
| TT | 49 (15.51) | 77 (24.37) | 1.0 (Ref.) | - |
| CT | 168 (53.16) | 163 (51.58) | 1.62 (1.05-2.52) | 0.02 |
| CC | 99 (31.33) | 76 (24.05) | 2.05 (1.25-3.36) | 0.003 |
| Allele | ||||
| T | 266 (42.09) | 317 (50.16) | 1.0 (Ref.) | - |
| C | 366 (57.91) | 315 (49.84) | 1.38 (1.10-1.74) | 0.004 |
| G2677T/A | ||||
| GG | 39 (12.34) | 51 (16.14) | 1.0 (Ref.) | - |
| GT/GA | 153 (48.42) | 149 (47.15) | 1.37 (0.83-2.26) | 0.19 |
| TT/AA | 124 (39.24) | 116 (36.71) | 1.43 (0.85-2.39) | 0.15 |
| Allele | ||||
| G | 231 (73.10) | 251 (39.72) | 1.0 (Ref.) | - |
| T/A | 401 (126.90) | 381 (60.28) | 1.15 (0.91-1.46) | 0.22 |
1
Adjusted for sex, age, smoking and drinking status.