Table 3.
Cox regression analysis of ABCB1 C3435T and G2677T/A polymorphisms with the PFS and OS of colorectal cancer
| Genotype | PFS | HR (95% CI)1 | P value | OS | HR (95% CI)1 | P value | ||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| Event (%) | Alive (%) | Death (%) | Alive (%) | |||||
|
|
|
|||||||
| N = 107 | N = 209 | N = 82 | N = 234 | |||||
| ABCB1 C3435T | ||||||||
| CC | 12 (11.21) | 37 (17.70) | 1.0 (Ref.) | - | 9 (10.98) | 40 (17.09) | 1.0 (Ref.) | - |
| CT | 50 (46.73) | 118 (56.46) | 1.57 (0.69-3.81) | 0.25 | 37 (45.12) | 131 (55.98) | 1.26 (0.54-3.21) | 0.58 |
| TT | 45 (42.06) | 54 (25.84) | 2.57 (1.14-6.04) | 0.01 | 36 (43.90) | 63 (26.92) | 2.54 (1.05-6.61) | 0.03 |
| Allele | ||||||||
| C | 74 (34.58) | 192 (45.93) | 1.0 (Ref.) | - | 55 (67.07) | 211 (90.17) | 1.0 (Ref.) | - |
| T | 140 (65.42) | 226 (54.07) | 1.61 (1.13-2.30) | 0.006 | 109 (132.93) | 257 (109.83) | 1.63 (1.11-2.41) | 0.009 |
| G2677T/A | ||||||||
| CC | 11 (10.28) | 28 (13.40) | 1.0 (Ref.) | - | 8 (9.76) | 31 (13.25) | 1.0 (Ref.) | - |
| CA | 50 (46.73) | 103 (49.28) | 1.24 (0.54-2.98) | 0.59 | 40 (48.78) | 113 (48.29) | 1.37 (0.56-3.74) | 0.47 |
| AA | 46 (42.99) | 78 (37.32) | 1.50 (0.65-3.66) | 0.31 | 33 (40.24) | 91 (38.89) | 1.41 (0.56-3.90) | 0.44 |
| Allele | ||||||||
| A | 72 (33.64) | 159 (38.04) | 1.0 (Ref.) | - | 56 (68.29) | 175 (74.79) | 1.0 (Ref.) | - |
| G | 142 (66.36) | 259 (61.96) | 1.21 (0.85-1.74) | 0.28 | 106 (129.27) | 295 (126.07) | 1.12 (0.76-1.67) | 0.54 |
1
Adjusted for tumor size, tumor differentiation, lymph mode metastases and relapse.