Table 2.
ORs and 95% CIs for OS in relation to polymorphisms of TP53 gene
| SNP | Genotypes | Cases, n (%) | Controls, n (%) | OR (95 CI)† | P trend |
|---|---|---|---|---|---|
| rs12951053 | AA | 54 (25.7) | 140 (33.3) | 1.00 | |
| AC | 103 (49.1) | 198 (47.2) | 1.35 (0.91-2.00) | ||
| CC | 53 (25.2) | 82 (19.5) | 1.68 (1.05-2.68) | 0.03 | |
| AC + CC | 156 (74.3) | 280 (66.7) | 1.45 (1.00-2.09) | ||
| rs1042522 | CC | 59 (28.2) | 162 (38.6) | 1.00 | |
| CG | 106 (50.7) | 194 (46.2) | 1.50 (1.03-2.20) | ||
| GG | 44 (21.1) | 64 (15.2) | 1.89 (1.16-3.07) | 0.007 | |
| CG + GG | 150 (71.8) | 258 (61.4) | 1.60 (1.11-2.29) | ||
| rs8064946 | GG | 68 (32.5) | 135 (32.1) | 1.00 | |
| GC | 100 (47.9) | 189 (45.0) | 1.05 (0.72-1.53) | ||
| CC | 41 (19.6) | 96 (22.9) | 0.85 (0.53-1.36) | 0.56 | |
| GC + CC | 141 (67.5) | 285 (67.9) | 0.98 (0.69-1.40) | ||
| rs9895829 | AA | 173 (82.8) | 350 (83.3) | 1.00 | |
| AG | 36 (17.2) | 70 (16.7) | 1.04 (0.67-1.62) | ||
| GG | - | - | - | - | |
| rs12602273 | CC | 89 (42.6) | 155 (36.9) | 1.00 | |
| CG | 93 (44.5) | 199 (47.4) | 0.81 (0.57-1.16) | ||
| GG | 27 (12.9) | 66 (15.7) | 0.71 (0.42-1.20) | 0.15 | |
| CG + GG | 120 (57.4) | 265 (63.1) | 0.79 (0.56-1.11) |
†
Adjusted for age.