Table 3.
Interaction of TNF-α polymorphism and hypoxia
| SNP | variable | Case | Control | OR (95% CI) | P value |
|---|---|---|---|---|---|
| rs1800629 | |||||
| + | + | 34 | 46 | 1 | |
| + | - | 41 | 27 | 2.054 (1.064-3.966) | 0.032 |
| - | + | 8 | 11 | 0.984 (0.357-2.709) | 0.791 |
| - | - | 37 | 16 | 3.129 (1.500-6.526) | 0.001 |
| rs1799964 | |||||
| + | + | 1 | 1 | 1 | |
| + | - | 4 | 2 | 2 (0.078-51.593) | 0.752 |
| - | + | 41 | 56 | 0.732 (0.044-12.051) | 0.645 |
| - | - | 74 | 41 | 1.805 (0.110-29.620) | 0.890 |
| rs1800630 | |||||
| + | + | 30 | 49 | 1 | |
| + | - | 24 | 18 | 2.178 (1.017-4.664) | 0.067 |
| - | + | 12 | 8 | 2.450 (0.898-6.682) | 0.113 |
| - | - | 54 | 25 | 3.528 (1.829-6.803) | 0.000 |
“+” for wild genotype, “-” for mutant genotype (SNP column); “-” for hypoxia , “+” for no hypoxia (variable column).