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CD271+ cells possess the ability to resist to conventional chemotherapeutic reagents in vitro. Surviving cells were detected in sorted CD271+ and CD271− cells treated with (A) DDP and (B) 5-FU by CCK8 assay. CD271 expression was analyzed in (D and F) DDP-, (E and G) 5-FU-resistant cells and (C) parent cells by flow cytometry.
