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letter
. 2015 Apr 11;11(6):629–632. doi: 10.7150/ijbs.11615

Figure 1.

Figure 1

PML is up-regulated in hepatocytes from obese individuals. (A-B) Description of the clinical features of obese subjects (A) in which PML transcript abundance (q-RT-PCR) was measured (B). (C-D). Pml transcript abundance (q-RT-PCR) (C) and immunoreactivity (D) in mice subjected to standard (chow) or obesity-inducing high-fat diets (HFD) (representative micrographs from n=4-5; squares represent zoomed region; red arrows depict PML immunoreactive hepatocytes; red asterisks depict PML immunoreactive non-hepatocyte cells). **, p<0.01 calculated by non-parametric Mann-Whitney test. (E) Pml, Sumo-1 and Nucleophosmin (Npm) immunoreactivity in livers from wild type or agouti heterozygous mutant mice (representative micrographs from n=3; squares, arrows and asterisks as described in D).