Figure 3.

P-selectin-mediated platelet adhesion promotes intestinal tumor growth in Apc^Min/+ mice. (A) Representative dissecting gross image of the middle small intestine from Apc^Min/+ and Apc^Min/+;P-sel^-/- mice. (B) The effects of P-selectin deficiency on the numbers of microadenomas, adenomas and total tumors. (C) The effects of P-selectin deletion on the tumor volumes of microadenomas, adenomas and total tumors. (D and E) Representative H&E stained images. The arrowheads indicate adenomas in the left image. The adenoma indicated by the green asterisk was further magnified in the right image. The adenomas in Apc^Min/+ mice and Apc^Min/+;P-sel^-/- mice were high-grade and low-grade, respectively. (F) The numbers of low- and high-grade adenomas in the small intestine of Apc^Min/+ mice and Apc^Min/+;P-sel^-/- mice. *, p<0.05; ***, p<0.001. Scale bars = 50 μm in E.