Table 1.

Binding modes of structurally characterized peptide/Hsp70 complexes

Chaperonea	Peptide	Subsite Bindingc	Orientation	Origin of Peptide	Ref
EC DnaK SBDb	NR		Forward	Phage Display	12
EC DnaK SBD	NR		Forward	Phage Display	14
EC DnaK SBD	LML		Forward	Phage Display Variant	14
HS HspA1 SBD	NR		Forward	Phage Display	13
GK DnaKd	Linker		Forward	Interdomain linker	20
EC DnaK SBD	LYZ		Forward	Antimicrobial pyrrhocoricin	14
EC DnaK SBD	1-11_LYZ		Forward	Antimicrobial pyrrhocoricin	14
EC DnaK SBD	1-10_LYZZ		Forward	Antimicrobial pyrrhocoricin	14
EC DnaK SBD	1-10_LYZI		Forward	Antimicrobial pyrrhocoricin	14
EC DnaK SBD	W/T		Forward	Antimicrobial pyrrhocoricin	14
EC DnaK SBD	Onc72		Forward	Antimicrobial onconin	14
EC DnaK SBD	1–15		Forward	Antimicrobial PR-39	14
EC DnaK SBD	1–20		Forward	Antimicrobial, designed	14
EC DnaK SBD	3–11		Forward	Antimicrobial apidaecin	14
EC DnaK SBD	4–11		Forward	Antimicrobial apidaecin	14
EC DnaK SBD	PL		Reverse	IscU, EC Fe-S assembly protein	15
EC DnaK SBD	PP		Reverse	Variant of IscU peptide	14
EC DnaK SBD	NR		Reverse	Phage Display Variant	14
EC DnaK SBD	3–11		Reverse	Apidaecin variant, Api88	16
EC DnaK SBD	12–20		Reverse	Antimicrobial pyrrhocoricin	14
EC DnaK SBD	12–19		Reverse	Antimicrobial drosocin	14
EC DnaK SBD	14–21		Reverse	Antimicrobial heliocin	14

^aEC denotes Escherichia coli; HS, Homo sapiens; GK, Geobacillus kaustophilus.

^bSBD constructs are from aa393 to aa603, E. coli numbering in all cases.

^cThe residue occupying the central pocket is shown in larger font. Residues in italics were outside the binding site and generally had high B factors.

^dConstruct is from aa1 to aa603.

^eZ Denotes cyclohexlyalanine.