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Potential roles of spacer DNA In “a” spacer DNA plays a passive role to position −10 and −35 element to allow recruitment of RNAP. In “b” the −35 contact induces an allosteric change in the protein that effects interactions of polymerase with −10 element. In “c” spacer DNA undergoes deformations triggered by initial RNAP interactions with −10 and −35 elements. In “d” spacer DNA undergoes deformations concomitant with promoter melting.
