Table 1. Comparison of eCLE (endoscope-based CLE), pCLE (probe-based CLE) and SECM.
| eCLE | pCLE | SECM | |
| Image acquisition speed | 0.8 frames/sec1 | 12 frames/sec2 | 100 frames/sec |
| Contrast mechanism | Fluorescence | Fluorescence | Reflectance |
| Contrast agent | Intravenous fluorescein | Intravenous fluorescein | Topical acetic acid |
| Implementation | Integrated in endoscope | Though an accessary port | Over a guide wire |
| Laser wavelength | 488 nm1 | 488 nm2 | 1300 nm |
| Resolution | Lateral: 0.7 µm1 Axial: 7 µm1 | Lateral: 1 µm2 Axial: 3 µm2 | Lateral: 2 µmAxial: 17 µm |
| Imaging depth | 0 – 250 µm1 | 0 – 50 µm3 | 86 – 114 µm4 |
| Field of view (FOV) | 500 × 500 µm2 1 | 240 × 200 µm2 2 | 280 × 1300 µm2 |
| Contiguous mosaic size | No published value available | 8 mm2 5 | 1,100 mm2 6 |
| Large-area imaging method | Manual scanning | Manual scanning | Automatic pullback |
1
These values were taken from Kiesslich et al. [1].
2
These values were taken from Becker et al. [6].
3
Imaging depth of pCLE can be set as a fixed value between 0 and 50 µm [16].
4
Multiple depth levels are imaged simultaneously over this range.
5
This value was taken from De Palma et al. [17].
6
This value is for a 5-cm-long pullback of the probe.