Figure 1.

Model of how mechanical strain within newly built bone packages induces coupling in cancellous bone remodeling. (A) After osteoclastic bone resorption has been completed, the resorption cavity results in mechanical weakening and increased strain in the bone spicule when loaded (large arrows). Mechanosensing osteocytes detect the increased strain and secrete osteogenic factors to induce osteoblastic bone formation. (B) Filling of the resorption cavity is controlled by mechanosensing in osteocytes embedded within the newly formed bone, signaling (small arrows) to osteoblasts on the bone surface.