Table I.
Age-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the association between postmenopausal body mass index (BMI) and breast cancer, as defined by gene-specific promoter methylation (comparing methylated vs. unmethylated cases), Long Island Breast Cancer Study Project (1996-1997).
| BMI (<25kg/m2) |
BMI (25-29.9kg/m2) |
BMI (≥30kg/m2) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Genes | Methylated/ Unmethylated |
OR | 95% CI | Methylated/ Unmethylated |
OR | 95% CI | Methylated/ Unmethylated |
OR | 95% CI |
| APC | 110/106 | 1.00 | reference | 90/89 | 0.97 | (0.65, 1.45) | 76/71 | 1.03 | (0.68, 1.57) |
| BRCA1 | 127/102 | 1.00 | reference | 117/76 | 1.24 | (0.84, 1.82) | 86/73 | 0.95 | (0.63, 1.42) |
| CDH1 | 16/193 | 1.00 | reference | 11/156 | 0.86 | (0.39, 1.91) | 6/143 | 0.50 | (0.19, 1.31) |
| CYCLIND2 | 43/166 | 1.00 | reference | 40/127 | 1.20 | (0.73, 1.97) | 33/116 | 1.15 | (0.69, 1.93) |
| DAPK | 29/180 | 1.00 | reference | 26/141 | 1.13 | (0.64, 2.01) | 27/122 | 1.43 | (0.81, 2.55) |
| ESR1 | 106/122 | 1.00 | reference | 81/110 | 0.85 | (0.58, 1.25) | 78/81 | 1.11 | (0.74, 1.66) |
| GSTP1 | 55/154 | 1.00 | reference | 46/121 | 1.06 | (0.67, 1.67) | 42/107 | 1.12 | (0.70, 1.79) |
| HIN | 118/91 | 1.00 | reference | 112/55 | 1.57 | (1.03, 2.39) | 97/52 | 1.44 | (0.94, 2.23) |
| CDKN2A | 7/202 | 1.00 | reference | 9/164 | 1.67 | (0.61, 4.61) | 6/137 | 1.28 | (0.42, 3.89) |
| PR | 34/196 | 1.00 | reference | 21/172 | 0.70 | (0.39, 1.25) | 15/144 | 0.60 | (0.31, 1.14) |
| RARB | 64/145 | 1.00 | reference | 49/118 | 0.93 | (0.60, 1.46) | 37/112 | 0.76 | (0.47, 1.23) |
| RASSF1A | 176/33 | 1.00 | reference | 146/21 | 1.28 | (0.71, 2.32) | 122/27 | 0.86 | (0.49, 1.52) |
| TWIST | 36/173 | 1.00 | reference | 30/137 | 1.05 | (0.61, 1.79) | 22/127 | 0.84 | (0.47, 1.51) |