Table 2.
Significantly Changed Genes (different doses common raised) Mapped to KEGG Pathways
| Pathway | Count | p-Value | q-Value | Gene |
|---|---|---|---|---|
| Cell adhesion molecules (CAMs) | 13 | 9.35E-12 | 6.95E-11 | Cdh1;RT1-N3;Cd8a;Jam3;Itgb7;Cd274;Cldn5;Cd8b; |
| Icam2;H2-T24;Itgam;Itgb2;Cldn4 | ||||
| Natural killer cell mediated cytotoxicity | 12 | 8.04E-11 | 3.78E-10 | Rac2;RT1-N3;Ptpn6;Lck;Grb2;Zap70;Icam2;H2-T24; |
| Tyrobp;Fcgr3;Itgb2;Prf1 | ||||
| Focal adhesion | 13 | 1.61E-10 | 6.43E-10 | Rac2;Fn1;Col5a1;Grb2;Itgb7;Fn1;Col1a2;Col1a1; |
| Col4a2;Col1a1;Col4a1;Tnn;Flna;Ccnd1;Myl9 | ||||
| Complement and coagulation cascades | 9 | 3.42E-10 | 1.27E-09 | C1qb;C4b |
| ;C1qa;C1r | ||||
| ;C1s;Cfb; | ||||
| C2;C6;Plau | ||||
| ECM-receptor interaction | 8 | 1.55E-08 | 3.84E-08 | Fn1;Col5a1;Itgb7;Fn1;Col1a2;Col1a1;Col4a2; |
| Col1a1;Col4a1;Tnn | ||||
| Leukocyte transendothelial migration | 9 | 4.12E-08 | 8.92E-08 | Rac2;Jam3;Cldn5;Thy1;Itgam;Itgb2;Cxcr4;Myl9;Cldn4 |
| Primary immunodeficiency | 6 | 6.53E-08 | 1.36E-07 | Cd8a;Ciita;Lck;Zap70;Rfxap;Cd8b |
| Arachidonic acid metabolism | 6 | 1.61E-06 | 2.61E-06 | Ephx2;Cyp2j4;Gpx3;Ptgs1;Pla2g10;Cbr1 |
| Systemic lupus erythematosus | 8 | 2.56E-06 | 4.04E-06 | C1qb;C4b;C1qa;C1r;C1s;C2;C6;Fcgr3 |
| Antigen processing and presentation | 7 | 2.92E-06 | 4.22E-06 | RT1-N3;Cd8a;Ciita;Rfxap;Cd8b;H2-T24;Cd74 |
| Regulation of actin cytoskeleton | 9 | 5.00E-06 | 7.03E-06 | Cfl1;LOC688430;Rac2;Fn1;Pip4k2a;Itgb7;Fn1; |
| Itgam;Itgb2;Myl9 | ||||
| T cell receptor signaling pathway | 6 | 6.53E-05 | 7.54E-05 | Cd8a;Ptpn6;Lck;Grb2;Zap70;Cd8b |
| Hematopoietic cell lineage | 5 | 1.02E-04 | 1.09E-04 | Cd8a;Csf1r;Anpep;Cd8b;Itgam |
| Axon guidance | 6 | 1.25E-04 | 1.30E-04 | Cfl1;LOC688430;Rac2;Slit3;Fes;Cxcr4 |
| Small cell lung cancer | 5 | 2.92E-04 | 2.62E-04 | Fn1;Nos3;Fn1;Col4a2;Col4a1;Ccnd1 |
| Citrate cycle (TCA cycle) | 3 | 7.92E-04 | 6.44E-04 | Pck1;Aco1;Acly |