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. 2015 May 21;5:10371. doi: 10.1038/srep10371

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A schematic representation of the mathematical model. After a virion, , successfully enters and infects a susceptible target cell, , at infection rate, , the newly infected cell progresses through different stages of cell populations, , which are structured according to the time elapsed, , since virus entry. Each of these stages has a corresponding age-dependent hazard rate, , for the probability that the newly infected cell in the eclipse phase transitions to the infectious state (i.e., becomes infectious, ) and begins virus production. An infectious, virus-producing cell, , produces progeny virions at constant rate , and dies at rate . The virions are cleared at rate .

Inline graphic — A schematic representation of the mathematical model. After a virion, , successfully enters and infects a susceptible target cell, , at infection rate, , the newly infected cell progresses through different stages of cell populations, , which are structured according to the time elapsed, , since virus entry. Each of these stages has a corresponding age-dependent hazard rate, , for the probability that the newly infected cell in the eclipse phase transitions to the infectious state (i.e., becomes infectious, ) and begins virus production. An infectious, virus-producing cell, , produces progeny virions at constant rate , and dies at rate . The virions are cleared at rate .