Table 1. Characteristics of studies included in the meta-analysis.
| First author | year | Country or area | Duration Month(s) | Histology | Stage | Patients n | Quality score | Detection | Cutoff values |
|---|---|---|---|---|---|---|---|---|---|
| Andersen16 | 2011 | Norway | 216 | NSCLC | I-IIIA | 335 | 9 | IHC (Notch1, DLL4) | Staining of H-score 0–1 vs. 2–3 |
| Baumgart8 | 2010 | Germany | NR | NSCLC | NR | 46 | 9 | IHC(Notch1) | Staining of H-score 0–1 vs. 2–3 |
| Bild17 | 2005 | USA | 90 | NSCLC | NR | 111 | 9 | RT-PCR(Notch1, DLL4, HES1) | median expression |
| Cao9 | 2012 | China | NR | NSCLC | I-IIIA | 131 | 8 | IHC(Notch1) | Staining of H-score0–1 vs. 2–3 |
| Hassan23 | 2013 | USA | 60 | ADC | I-III | 441 | 9 | IHC(HES1) | median H-score |
| Hou20 | 2010 | Netherland | 130 | NSCLC | NR | 156 | 9 | RT-PCR (Notch1, HES1) | median expression |
| Lee24 | 2008 | Korea | NR | NSCLC | I-III | 158 | 8 | IHC(Notch1) | >10% |
| Li10 | 2009 | USA | NR | NSCLC | NR | 127 | 9 | IHC(Notch1) | median H-score |
| Li11 | 2010 | USA | NR | NSCLC | I-IV | 395 | 8 | IHC(Notch1) | Staining of H-score 0–1 vs. 2–3 |
| Okayama18 | 2011 | Japan | 120 | ADC | NR | 226 | 9 | RT-PCR(Notch1, DLL4, HES1) | median expression |
| Peng12 | 2011 | China | NR | NSCLC | NR | 55 | 7 | IHC(Notch1) | median H-score |
| Pesch13 | 2012 | Germany | NR | NSCLC | NR | 68 | 7 | IHC(Notch1) | Staining of H-score 0–1 vs. 2–3 |
| Raponi22 | 2006 | USA | 60 | SCC | I-IIIA | 20 | 7 | RT-PCR(HES1) | median expression |
| Shi28 | 2014 | China | 24 | NSCLC | III-IV | 594 | 8 | IHC(Notch3) | median H-score |
| Westhoff19 | 2009 | Italy | 60 | NSCLC | I-IV | 420 | 9 | IHC(Notch1) | median H-score |
| Xin14 | 2007 | China | NR | NSCLC | I-III | 80 | 8 | IHC(Notch1) | Staining of H-score 0–1 vs. 2–3 |
| Ye27 | 2013 | China | 60 | NSCLC | I-IV | 131 | 8 | IHC(Notch3) | median H-score |
| Zhang15 | 2013 | USA | NR | NSCLC | I-IV | 41 | 8 | IHC(Notch1) | Staining of H-score 0–1 vs. 2–3 |
| Zhu21 | 2010 | Canada | 120 | NSCLC | I-II | 133 | 9 | RT-PCR(HES1) | median expression |
Abbreviation: NR, not reporting; IHC, immunohistochemistry; RT-PCR, real-time reverse transcription polymerase chain reaction; ADC, lung adenocarcinoma; SCC, lung squamous cell carcinoma.