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. Author manuscript; available in PMC: 2015 May 21.
Published in final edited form as: Mol Carcinog. 2011 Aug 18;51(9):734–745. doi: 10.1002/mc.20840

Figure 2. UVB induces β-catenin/TCF-dependent transcriptional activity in keratinocytes.

Figure 2

(A) The dual luciferase assay was performed on 308 cells which were transiently transfected with TOP- or FOPflash reporter constructs and Renilla and 24 hrs later sham irradiated or exposed to 500 J/m2 UVB (8 hrs). Results are mean ratio of TOPflash luciferase activity to FOPflash luciferase activity (TOP/FOP) from three independent experiments ± SEM. (B) 308 cells and NHEKs were exposed to sham or 500 J/m2 UVB and incubated for 8 hrs. Total RNA was harvested and real time RT-PCR was performed. Results are the mean of at least three independent experiments ± SEM. *, P < 0.02; **, P < 0.01.