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. Author manuscript; available in PMC: 2015 May 21.
Published in final edited form as: Mol Carcinog. 2011 Aug 18;51(9):734–745. doi: 10.1002/mc.20840

Figure 4. Accumulation of β-catenin induced by UVB is mediated by the EP2 receptor.

Figure 4

(A) NHEKs were treated with DMSO vehicle control or the indicated doses of PGE2 for 15 mins and cell lysates were immunoblotted with antibodies for the indicated proteins. (B) 308 cells and (C) NHEKs were pre-treated with DMSO vehicle control [D] or the indicated doses of AH6809. Cells were then sham irradiated or exposed to 500 J/m2 UVB and incubated for 8 hrs. Cell lysates were analyzed by immunoblotting for unphospho-β-catenin, total β-catenin and GAPDH. Representative blots are shown and numbers indicate fold change of proteins normalized to GAPDH.