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. 2015 Apr 30;4:13. doi: 10.1186/s40164-015-0007-0

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© Robles et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Chemokine expression in host spleen and target organs. (A) RANTES expression. (B) Expression of CCL3 and CXCL9. (C-D) Expression of CCR5, CXCR3 and CCR7. Lethally irradiated BALB/c host mice were given intravenous injections of 2 × 10^6 TCDBM cells from C57BL/6 donors with or without 0.25 × 10 ^6 CD4+ T cells from donors and 1 × 10 ^6 hMSCs. (A) Host spleen and colon were harvested 6d after transplantation and RANTES expression measured using ELISA (*p = 0.0356). Data were combined from 2 independent experiments with 3-4 mice in each experiment. (B) Expression of CCL3 and CXCL9 6d after transplantation in BALB/c host spleen, colon and lung were measured by RT-qPCR. Data were combined from 2 independent experiments with 4-6 mice. (C,D) Expression of CCR5, CXCR3 and CCR7 6d after transplantation in BALB/c host spleen were measured by using trypan blue cell exclusion assay and flow cytometry and expressed in absolute numbers of CD3+ CCR5+, CD3+ CXCR3+ (C) and CD3+ CCR7+ (D) splenocytes. Data were combined from 2 independent experiments with 2-4 mice in each experiment (*p<0.005).