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. 2015 May 14;14:200. doi: 10.1186/s12936-015-0708-1

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© Mata-Cantero et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Correlation between AlphaLISA and DELFIA assays. A. Dose–response curves of known proteasome inhibitors in TUBE-AlphaLISA (left panel) and TUBE-DELFIA assays (right panel). The response is represented as a percentage of inhibition, which is calculated normalizing the data to the maximal signal obtained for each compound (see data analysis section). B. Correlation of pIC50s in TUBE-AlphaLISA and TUBE-DELFIA assays (average of at least 2 copies). Each point corresponds to a particular proteasome inhibitor. Interassay accuracy, Pearson’s correlation and CCC (the multiplication of both values) are shown. Grey line represents perfect correlation (y = x) while black doted lines are the perfect correlation ± 1 log unit (y = x ± 1). C. Correlation of the average of pIC50 obtained in the AlphaLISA and DELFIA assays vs reported pIC50 that produce the parasite growth inhibition in the whole cell assay.