Table 1.
Selected HDAC % inhibition data for compounds 9-24.a
![]() | |||||
---|---|---|---|---|---|
R | HUAC 1 | HUAC 2 | HUAC 6 | HDAC 10 | |
9 |
![]() |
63 | 30 | 50 | 49 |
10 |
![]() |
61 | 54 | 62 | 47 |
11 |
![]() |
44 | 35 | 49 | 36 |
12 |
![]() |
36 | 29 | 48 | 70 |
13 |
![]() |
62 | 32 | 46 | 59 |
14 |
![]() |
61 | 52 | 48 | 49 |
15 |
![]() |
48 | 45 | 40 | 45 |
16 |
![]() |
42 | 36 | 31 | 45 |
17 |
![]() |
35 | 25 | 46 | 32 |
18 |
![]() |
27 | 0 | 27 | 57 |
19 |
![]() |
43 | 1 | 50 | 91 |
10 |
![]() |
32 | 19 | 21 | 76 |
21 |
![]() |
-- | -- | -- | -- |
22 |
![]() |
70 | 57 | 60 | 47 |
23 |
![]() |
47 | 41 | 31 | 56 |
24 |
![]() |
26 | 32 | 60 | 55 |
Data shown was determined at a 20 μM concentration of each compound. Data points are the average of 3 determinations that in each case differed by 5% or less. Compound 21 was insoluble.