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. 2015 May 21;11(5):e1004858. doi: 10.1371/journal.ppat.1004858

Fig 5. Acute, but not latent, MHV68 infection results in suppressed humoral response.

Fig 5

(A) Timeline of infection. C57BL/6 mice were infected with 1000 PFU of MHV68 IN at day -60, -30, -15 or -7 and challenged with 105 pRBCs on day 0. Absolute number of (B) splenic GC B cell (B220+ GL7+ CD95+) and plasma cell (CD3- B220int CD138+) populations at day 16 post P. yoelii XNL infection (For GC and PC: Day -7 and Day -15 co-infected vs. P. yoelii, Kruskal Wallis p<0.05; Dunn’s pairwise comparison test p<0.05/ Day -30 co-infected vs. P. yoelii, Kruskal Wallis p<0.05; Dunn’s pairwise comparison test p>0.05). (C) MHV68 and P. yoelii XNL specific IgG responses at day 16 post P. yoelii XNL infection (Day -7 and Day -15 co-infected vs. P. yoelii, Kruskal Wallis p<0.05; Dunn’s pairwise comparison test p<0.05/ Day -30 co-infected vs. P. yoelii, Kruskal Wallis p<0.05; Dunn’s pairwise comparison test p>0.05). (D) Global Tfh population (CD4+ PD-1+ CXCR5+), germinal center Tfh (CD4+ GL7+ CXCR5+) and activated/antigen specific Tfh (CD4+ CD44+ PD-1+ CXCR5+) in the spleen at day 16 post P. yoelii XNL infection.