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. 2015 May 21;11(5):e1004858. doi: 10.1371/journal.ppat.1004858

Fig 6. The MHV68 M2 gene product is necessary for virus mediated humoral suppression and lethality during Plasmodium co-infection.

Fig 6

(A) MHV68 specific IgG titers from serum of animals infected with the MR (M2.Marker Rescue) or M2.Stop (ST, M2-null) viruses. Serum was collected and analyzed on days 7, 14 and 21 post infection with either virus (n = 10/ virus) (Day 21, MR vs. M2.Stop, Kruskal Wallis p<0.05; Dunn’s pairwise comparison test p<0.05). (B) P. yoelii XNL specific IgG response during P. yoelii XNL co-infection with either the M2.MR or M2.Stop virus. Serum was collected at day 20 post infection with P. yoelii XNL (WT + P. yoelii co-infected vs. P. yoelii, Kruskal Wallis p<0.05; Dunn’s pairwise comparison test p<0.05/ WT + P. yoelii co-infected vs. M2.Stop + P. yoelii, Kruskal Wallis p<0.05; Dunn’s pairwise comparison test p>0.05). (C) Survival curve during P. yoelii XNL co-infection with either the M2.MR or M2.Stop virus. Note: data representing P. yoelii XNL + MHV68 co-infection is the identical data set to that in Fig 1B. It was added in panel C for comparative purposes. (D) % parasitemia in the periphery during P. yoelii XNL, P. yoelii XNL +MR and P. yoelii XNL + M2.Stop infection.