Fig 4. High selectivity in mitochondrial fusion and mitophagy providing efficient removal of mutant mDNA.

(A & B) Model simulations with high mitophagy selectivity (r _D,max = 199) and non-selective fusion for (A) mutations without RA and (B) with RA (k _R = 2). (C & D) Model simulations with high fusion selectivity (r _fusi,max = 100%, r _D,max = 5) for (C) mutations without RA and (D) with RA. The error bars represent the standard deviation of ${\overline{R}}_M^{Cell}\left(t\right)$ among 10,000 cells.