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. 2015 May 21;10(5):e0125783. doi: 10.1371/journal.pone.0125783

Fig 1. MTSS1 is upregulated in t(8;21) and inv(16) AML patients.

Fig 1

The gene expression profiling of MTSS1, DNMT3B and DNMT3A in different AML subsets (GEO accession number GSE1159) is shown (A and B). MTSS1 mRNA levels were measured by qRT-PCR in human AML cell lines carrying either a FLT3-ITD mutation (MV4-11), t(15;17) (NB4), t(8;21) (Kasumi-1) or undefined genetic changes (U937) in relative expression to GAPDH (n = 3; C) which was verified at the protein level by Western Blot analysis using GAP-DH as a loading control (D).