Table 1. Genes misregulated by Lamin C ΔN and G489V.
| Gene symbol | Gene name | WT vs ΔN | WT vs G489V | Function | ||
|---|---|---|---|---|---|---|
| Fold change | p value | Fold change | p value | |||
| Cyp4p2 | Cyp4p2 | 144.40 | 7.53E-07 | 71.70 | 1.85E-06 | Electron carrier activity; heme binding; iron ion binding; oxidoreductase activity* |
| PlexB | Plexin B | 23.84 | 4.09E-08 | 34.56 | 2.11E-08 | Axon guidance |
| CG9935 | - | 8.77 | 4.18E-06 | 3.48 | 1.03E-05 | Glutamate gated ion channel activity* |
| CG34007 | - | 7.96 | 7.33E-05 | 33.49 | 3.47E-06 | Unknown |
| CG1074 | - | 7.36 | 2.87E-07 | 2.14 | 8.15E-05 | Methyltransferase activity; nucleic acid binding* |
| CG31781 | - | 5.50 | 5.18E-06 | 4.21 | 3.05E-04 | Lateral inhibition in cell fate determination |
| GstD9 | Glutathione S transferase D9 | 4.91 | 9.40E-05 | 8.66 | 1.63E-05 | Glutathione transferase activity |
| CG2064 | - | 4.21 | 1.43E-04 | 5.88 | 4.35E-05 | Oxidoreductase activity* |
| CG32021 | - | 3.39 | 3.25E-05 | 2.68 | 2.11E-04 | Lateral inhibition in cell fate determination |
| CG14906 | - | 3.72 | 4.37E-06 | 4.34 | 2.27E-06 | Methyltransferase activity; nucleic acid binding* |
| CG33494 | - | 3.60 | 9.57E-05 | 3.42 | 1.21E-04 | Unknown |
| Arc1 | Activity-regulated cytoskeleton associated protein 1 | 2.89 | 4.82E-05 | 3.07 | 3.47E-05 | Nucleic acid binding; zinc ion binding* |
| CG3448 | - | 2.41 | 5.93E-05 | 6.14 | 8.68E-07 | DNA binding* |
| alphaTub84D | alpha-Tubulin at 84D | 2.39 | 7.62E-05 | 2.66 | 3.93E-05 | GTP binding; GTPase binding; structural constituent of cytoskeleton*; Myosin binding |
| RpS11 | Ribosomal protein S11 | 2.04 | 2.74E-05 | 2.01 | 3.06E-05 | Structural constituent of ribosome* |
| CG16787 | - | 2.03 | 2.18E-05 | 3.01 | 1.48E-06 | Unknown |
| Sclp | Sclp | -2.49 | 7.23E-06 | -3.88 | 7.11E-07 | Muscle function |
| CG10365 | - | -2.54 | 1.77E-04 | -4.20 | 1.51E-05 | Unknown |
| NnaD | Nna1 ortholog | -2.56 | 4.34E-05 | -2.46 | 5.55E-05 | Metallocarboxypeptidase activity; purine nucleotide binding; zinc ion binding*; larval and neural retina development; mitochondrion organization |
| l(2)03659 | lethal(2)03659 | -5.08 | 1.47E-06 | -4.60 | 2.13E-06 | ATP binding; ATPase activity; transporter activity* |
| gkt | glaikit | -6.31 | 1.60E-07 | -5.04 | 3.46E-07 | 3’-tyrosyl-DNA phosphodiesterase activity*; nervous system development; epithelial cell apical/basil polarity |
*Inferred from amino acid sequence