Table 3. Concentration response data for the different antioxidants with 1 hour pre-incubation time (n = 10, repeated 3 times for each volunteer).
Antioxidant | Without antioxidant | 1/100 x SC | 1/10 x SC | 1 x SC | 10 x SC | 100 x SC |
---|---|---|---|---|---|---|
Zinc | 0.144 ± 0.008 | 0.150 ± 0.005 | 0.151 ± 0.004 | 0.151 ± 0.007 | 0.145 ± 0.005 | 0.144 ± 0.004 |
Trolox | 0.143 ± 0.005 | 0.141 ± 0.005 | 0.139 ± 0.010 | 0.137 ± 0.008 | 0.145 ± 0.011 | 0.137 ± 0.011 |
Lipoic acid | 0.164 ± 0.004 | 0.160 ± 0.002 | 0.156 ± 0.002 | 0.157 ± 0.007 | 0.153 ± 0.007 | 0.151 ± 0.011 |
ß-carotene | 0.150 ± 0.007 | 0.135 ± 0.007* | 0.131 ± 0.007* | 0.128 ± 0.006* | 0.129 ± 0.006* | 0.129 ± 0.004* |
Selenium | 0.155 ± 0.011 | 0.144 ± 0.008* | 0.140 ± 0.007* | 0.133 ± 0.006* | 0.140 ± 0.005* | 0.140 ± 0.004* |
Vitamin E | 0.163 ± 0.007 | 0.150 ± 0.005* | 0.145 ± 0.004* | 0.144 ± 0.004* | 0.150 ± 0.007* | 0.147 ± 0.005* |
Vitamin C | 0.146 ± 0.008 | 0.133 ± 0.004* | 0.133 ± 0.005* | 0.125 ± 0.004* | 0.118 ± 0.005* | 0.109 ± 0.004* |
NAC | 0.150 ± 0.009 | 0.146 ± 0.009 | 0.133 ± 0.005* | 0.115 ± 0.004* | 0.094 ± 0.008* | 0.086 ± 0.006* |
Q 10 | 0.136 ± 0.015 | 0.136 ± 0.008 | 0.124 ± 0.007 | 0.121 ± 0.011 | 0.112 ± 0.009* | 0.114 ± 0.060* |
The numbers indicate mean values and standard deviations of x-ray induced γ-H2AX-foci (excess foci)/cell after irradiation with 10 mGy.
* indicates a significant deviation from the base level without antioxidant (p <0.05) using Dunnett's test.