Table 2.
Minimum inhibitory concentration (MIC) values of synthesized peptides. The MIC is defined as the lowest concentration required to inhibit visual growth of bacteria.
| Peptide | MIC [μm]a | |||
|---|---|---|---|---|
| B. subtilis | S. epidermidis | E. coli | E. aerogenes | |
| Anoplin | 4 | 8 | 16 | >32 |
| DAH–anoplin | 2 | 16 | 8 | >32b |
| GGH–anoplin | 2 | 8 | 4 | >32b |
| VIH–anoplin | 0.5 | 2 | 2 | 32[b] |
| PAP | 0.5 | 4 | 1 | >32 |
| DAH–PAP | 0.25 | 4 | 0.25 | >32b |
| GGH–PAP | 0.125 | 1 | 0.125 | >32b |
| VIH–PAP | 0.125 | 0.25 | 0.25 | 32[b] |
| sh-Buforin | 8 | 8 | 32 | >32 |
| DAH–sh-buforin | 2 | 4 | 16 | >32b |
| GGH–sh-buforin | 4 | 16 | 16 | >32b |
| VIH–sh-buforin | 2 | 8 | 8 | >32b |
a
Data are the mode of three independent experiments. Mann–Whitney test was used to compared these results with those of the parental AMP; numbers in bold correspond to P≤0.05; all other results are not statistically significant.
b
Chi-square (Χ2) test was performed due to presence of ties.